University Catalog 2005-2006

Biodefense (BIOD)

Molecular and Microbiology

601 Foundations of Biodefense Science and Technology I (3:3:0) Basic biology of living systems including cell structure and function, metabolism, genetics, and bio-diversity. Areas covered are important to comprehending the technology and systems involved in biodefense. May not be used for credit toward a graduate degree in biodefense.

602 Foundations of Biodefense Science and Technology II (3:3:0) Required course that covers basic chemical and physical science topics behind biodefense. Areas covered are important to comprehending technology and systems involved. May not be used for credit toward the masterÕs degree in biodefense.

603 Introduction to Biodefense: Fundamentals of Microbiology (3:3:1) Prerequisites: BIOD 601 and 602, or equivalents. Lecture and laboratory course that emphasizes basic principles of microbiology, including virology and mycology. Structure, metabolism, genetics, and virulence properties of infectious microorganisms are stressed as well as the immune response to microorganisms. Laboratory covers basic techniques of isolation, propagation, and identification of microbes. Not available to students who have had a course in microbiology. May not be used for credit toward the masterÕs degree in biodefense.

604 Introduction to Biodefense/Threat Analysis I: Bacterial Agents (3:3:0) Prerequisites: BIOD 601, 602, and 603, unless waived. Required course that covers the pathology, metabolism, and threat of bacterial agents that can be utilized as biological weapons. Subjects include Bacillus anthracis, Yersinia pestis, and others chosen by instructor.

605 Introduction to Biodefense/Threat Analysis II: Viral Agents (3:3:0) Prerequisites: BIOD 601, 602, and 603, or permission of instructor. Required course that covers pathology, metabolism, and threat of viral agents that can be utilized as biological weapons. Subjects include Variola (smallpox), hemorrhagic fevers (Marburg, Ebola, Dengue) and others chosen by instructor.

606 Introduction to Biodefense/Threat Analysis III: Agricultural Biodefense (3:3:0) Prerequisites: BIOD 601, 602, and 603, or permission of instructor. Covers agents that can be utilized for the disruption of agriculture and livestock. Fungal, bacterial, and viral agents are discussed as well as local and global economic and social impact of disruption of food supplies.

607 Introduction to Biodefense/Threat Analysis IV: Toxins (3:3:0) Prerequisites: BIOD 601, 602, and 603, unless waived. Required course discussing the threat of toxins as biological weapons. Special focus on microbiological toxins including botulinum toxin, and biochemical action of toxins. Comparison to chemical weapons and debate about classification as such.

610. Advanced Topics in Biodefense (1-4:1-3:0-6) Prerequisite: permission of instructor.Different topics in different years, depending on instructorÕs specialty. Topics include legal, ethical, scientific, and political aspects of biodefense, emphasizing current problems and research. May be repeated.

702 Special Topics in Biodefense Seminar (1:1:0) Prerequisite: BIOD 601, 602, 603, 604, and 605; or permission of instructor. In-depth examination of advanced topics in defense against biological agents. Topic depends on instructorÕs specialty. May be repeated for credit with advisorÕs permission.

703 Special Topics in Biodefense Seminar (Presenting) (1:1:0) Prerequisite: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Student research and presentations on approved topic. May be repeated for credit with advisorÕs permission.

704 Principles of Toxicology (3:3:0) Prerequisite: courses in physiology and biochemistry, or permission of instructor. Introduction to scientific principles and biological underpinnings of toxicology. Surveys the processes of absorption, distribution, metabolic transformation, and elimination of foreign substances in the body, as well as mechanisms of toxicity. Students gain understanding of genetic toxicology, cancer formation, developmental and reproductive toxicology, and target organ toxicology (including effects on blood, liver, and skin; and urinary, cardiovascular, respiratory, nervous, and immune systems) Concludes with overview of several types of toxic agents and their interactions with biological systems.

705 Detecting Production of Biological Agents (2:2:0) Prerequisite: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Involves the study of detection techniques for biological weapon-production facilities. Major goal is to show students the difference in detecting a large-scale, state-run facility and detecting a home laboratory. In addition, students learn the differences between illicit biological agents versus biological agents used for pharmaceutical research.

706 History of Biological Agent Use and Treaties (3:3:0) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Lecture course on historical uses of biological weapons as well as treaties signed by various countries and powers concerning their use.

707 Detection Techniques in a Bioterror Attack (3:3:0) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Involves the study of detection techniques for a biological weapon that has been released in various forms. Students gain understanding of how different detectors work, and how to interpret data these detection devices collect.

708 Epidemiology of a Bioterror Attack (3:3:0) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Teaches basics of epidemiology as well as unique issues in epidemiology that biological agents used as weapons present. Includes how disease would spread naturally, but also how to prevent it from spreading, and differences in natural and unnatural outbreaks.

709 Nonproliferation in Biodefense (3:3:0) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Involves current issues in nonproliferation of biological agents as a weapon of mass destruction. Students study various theories in nonproliferation, and look at nonproliferation in practice in recent history.

710 Approaches to Bioweapon Medical Treatment and Response (3:3:0) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Involves research, treatment, and preparedness strategies against biological agents. Focuses on various strategies including immunological, pharmaceutical, and medical treatment methodologies and designs.

711 Techniques in Immunology Lecture (3:3:0) Prerequisites: BIOD 601, 602, 603, 604, and 605, or permission of instructor. Introduces theory of immunological techniques and their application.

712 Techniques in Immunology Laboratory (1:0:3) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Prerequisite or corequisite: BIOD 711. Laboratory techniques discussed in BIOD 711 including enzyme-linked immunosorbant assay, protein electrophoresis, FLOW cytometry, and vaccine preparation. Not available to students who have had an undergraduate laboratory course in immunology.

721 Coordinated Response to a Bioterror Attack (2:2:0) Prerequisite: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Provides information for defending against biological attacks. Includes on-scene procedures following the initial discovery of such agents, site boundaries for biological agents, gross decontamination procedures, site set-up procedures, agent removal, and case studies of hypothetical infections. Students learn critical response requirements of biological attack.

722 Examining Terrorist Groups (3:3:0) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. History of known organized terrorist activity, including study of common cultural and historical correlations, groupsÕ modus operandi, and latest developments in terrorist profiling.

723 Counterterrorism and Civil Rights (3:3:0) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Analysis of legal issues associated with counterterrorism surveillance, interrogation, search, detainment, and decontamination in the context of civil rights and rule of law.

724 Incident Response Information Technology (2:2:0) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Effective information-sharing on bioterrorist incidents among federal, state, and local law enforcement agencies through databases and computer software.

742 Modern Geographic Techniques in Detection as Tracking (3:3:0) Prerequisites: GEOG 300 and 311, or permission of instructor. Elective course on the utilization of GIS, remote sensing/satellite imagery, and spatial analysis techniques that can be used to monitor biological events and plan and coordinate response.

761 Dispersal Patterns of Biological Agents (3:3:0) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Introduction to military and terrorist methods of dispersal patterns. Course covers physics of aerosols, engineering and mechanics of building ventilation systems, and mechanical dissemination including hand-held, automatic, vehicle, and truck-mounted systems. Also covers viability of specific agents involved.

762 Into the Hot Zone: Working in a High Threat Environment (2:2:0) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Introduction course includes methodology of working in a Biosafety Level 3 or 4 environment. Special attention on responding to a biowarfare or bioterrorism related event.

763 History of Genetically Engineered Bioweapons (2:2:0) Prerequisites: BIOD 601, 602, 603, 604, and 605; or permission of instructor. Covers history of genetic manipulation of bioweapons. Special attention to advent of molecular techniques, as well as the general microbiology techniques in making strains of both pathogenic and nonpathogenic organisms more virulent or survivable.

764 Engineering Immunology and Immune Drug Development (2:2:0-6) Prerequisite: two of the following: BIOD 604, 605, 606 or 607. Elective course covers traditional and novel methods employed in engineering immunology, as well as methods and equipment for immunomodulating drug development. Emphasis on various methods and techniques to develop protection against BW infections and naturally occurring infections using substances to modulate the host immune response.

765 Drug Discovery and Development (2:2:0-6) Prerequisite: 400-level chemistry and molecular biology courses, or permission of instructor. Covers all steps of drug discovery and development process from target identification to clinical studies. Emphasizes main approaches and tools utilized in modern drug discovery.

766 Bioengineering and Bioprocessing (2:2:0-6) Prerequisite: two of the following: BIOD 604, 605, 606 or 607. Elective course covers methods, means and processes necessary to research, develop, and manufacture biologicals and pharmaceuticals, which are important in the field of medical biodefense. Emphasizes laboratory pilot plant and industrial production of diagnostic and prophylactic means, as well as therapeutics that could be used for both medical biodefense and civilian medicine purposes.

780 Masters Supervised Internship (1-8:0:0) Prerequisite: permission of program director or advisor. An internship for masterÕs students dealing with application of principles presented in courses within a concentration, under the supervision of qualified professional in the field of biodefense at a government agency, consulting firm, industrial firm, or other acceptable agency.

783 Laboratory Rotation (1:0:4) Prerequisite: permission of instructor. Intensive introduction to research laboratory in the biosciences. Students read background material pertinent to the problem under study, learn and practice research methods of the laboratory, and formulate a short final project, which may be a proposal or an actual project, demonstrating some mastery of techniques and approaches employed.

793 Directed Studies in Biodefense (1-8:0:0) Prerequisite: permission of the instructor, department chair, and studentÕs graduate committee. Study of specialized topics not otherwise available in graduate program. May involve any combination of reading assignments, tutorials, lectures, papers, presentations, or lab or field study, determined in consultation with instructor. Specific arrangements for designing the scope and area of study to be determined in consultation with instructor. May be repeated for credit with permission of instructor or graduate program director.

798 MasterÕs Research Project in Biodefense (1-3:0:0) Prerequisites: 8 graduate credits in BIOD course, and permission of major professor and department chair. Experimental or theoretical research project chosen and completed under guidance of graduate faculty member. Requires comprehensive report acceptable to the studentÕs advisory committee. Graded S/NC.

799 MasterÕs Thesis in Biodefense (3-6:0:0) Prerequisites: 8 credits in BIOD and permission of instructor and department chair. MasterÕs thesis research under direction of supervisor. Graded S/NC.

890 Doctoral Supervised Internship (1-6:0-6:0-18) Prerequisite: permission of program director and studentÕs doctoral committee. Internship dealing with the application of principles presented in courses within a concentration under the supervision of a qualified professional in the field of biodefense at a government agency, consulting firm, industrial firm, or other acceptable agency.

899 Directed Research in Biodefense (1-12:0:0) Prerequisites: permission of research advisor. Research on a pertinent topic in biodefense. Scope and subject of research determined by instructor.

996 Doctoral Reading and Research (1-9:0:0) Prerequisites: admission to doctoral program, and permission of advisor and committee. Reading and research on a specific topic in biodefense under direction of a faculty member. Specific arrangements for designing scope and area of study to be determined in consultation with instructor. May involve literature searches and review, workshops, tutorials, or other formats. May be repeated for credits.

998 Doctoral Dissertation Proposal (1-12:0:0) Prerequisite: admission to doctoral candidacy, or approval of doctoral program director. Development of a research proposal, which forms the basis for doctoral dissertation under guidance of dissertation director and doctoral committee. May be repeated, but only 12 credits may be applied to the degree. Graded S/NC.

999 Doctoral Dissertation (1-12:0:0) Prerequisite: approved doctoral proposal. Doctoral dissertation research under direction of dissertation director. May be repeated for no more than a total of 24 credits of BIOD 998. BIOD 999 may be applied toward doctoral degree. Graded S/NC.