COURSE DESCRIPTION
An intense overview of cellular neuroscience for graduate students interested in studying how nerve cells integrate and transmit signals, and how behavior emerges from the integrated actions of populations or circuits of nerve cells. The course covers electrical and biochemical properties of single neurons, and electrical and chemical communication between neurons.
SYLLABUS (Tentative)
| WEEK/DATE | TOPIC | READING |
| 1 08/29 |
Introduction; Ultrastructure; Axon Guidance and Cell Migration lecture | FN Chap 15, 17; LK 17; PNS Chap 4 Paper |
| 2 09/05 |
Glia; Neuronal types / Morphology lecture | FN Chap 2 and 3; LK Chap 1; PNS Chap 2 Paper |
| 3 09/12 |
Organelle Function lecture | FN Chap 4; LK Chap 2; PNS Chap 4,5 Paper |
| 4 9/19 |
Resting potential and Ion pumps lecture | FN Chap 6, LK Chap 3; PNS Chap 7 Paper |
| 5 9/26 |
Ionic Channels lecture | LK Chap 4,5; PNS Chap 6 paper |
| 6 10/4 |
Action Potentials lecture | FN Chap 6, LK Chap 6; PNS Chap 9 paper |
| 7 10/10 |
Diversity, Synthesis of Neurotransmitters lecture | FN Chapter 7, LK Chap 8,10; PNS Chap 15 paper |
| 8 10/17 |
MIDTERM (Lectures 1-6) | |
| 9 10/24 |
Transmitter release, plasticity lecture | FN Chapter 8, LK Chap 9; PNS Chap 14 paper |
| 10 10/31 |
Neurotransmitter receptors, Postsynaptic potentials, Gap junctions lecture | FN Chapter 9,11 LK Chap 8, 11;PNS Chap 11, 12 paper |
| 11 11/07 |
SFN - No Class | |
| 12 11/14 |
Signal Propagation and Integration lecture | FN Chapters 5, 12; PNS Chap 8 paper |
| 13 11/28 |
Neuromodulators and second messengers lecture | FN Chapter 9, 10, LK Chap 12,13; PNs Chap 13 paper |
| 14 12/5 |
Sensory Receptors lecture | FN Chapters 23,24, LK Chap 14; PNS Chap 21, 26, 31, 32 |
| 12/12 | FINAL, 12:00 pm - 2:45 PM (Lectures 7-14) |
TEXT
PNS (required): Kandel, Schwartz, Jessel Principles of Neural Science, 5th Ed., 2007
FN (alternate to required): Zigmond, Bloom, Landis, Roberts, Squires Fundamental Neuroscience, 2nd ed. Academic Press, 2003
LK (recommended): Levitan and Kaczmarek, The Neuron: Cell and Molecular Biology,3rd
Edition Oxford University Press, 2002