CBEL Publications.
Evaluation of 3D Reconstruction Algorithms for a Small Animal PET Camera
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Authors:
- Johnson CA, Seidel J, Carson RE, Gandler WR, Sofer A, Green MV, Daube-Witherspoon ME
- Formats:
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This publication is available in Adobe's PostScript and Adobe's Portable Document Format.
- Published:
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IEEE Transactions on Nuclear Science vol 44 no 3 (July 1997)
- Abstract:
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The use of paired, opposing position-sensitive phototube scintillation
cameras (SCs) operating in coincidence for small animal imaging
with positron emitters is currently under study. Because of
the low sensitivity of the system even in 3D mode and the need
to produce images with high resolution, it was postulated that
a 3D expectation maximization (EM) reconstruction algorithm
might be well suited for this application. We investigated six
reconstruction algorithms for the 3D SC PET camera: 2D
filtered back-projection (FBP), 3D reprojection (3DRP), 2D EM
3D EM, 2D ordered subset EM (OSEM), and 3D OSEM. Noise was
assessed for all slices by the coefficient of variation in a
simulated uniform cylinder. Resolution was assessed from a
simulation of 15 point sources in the warm background of the
uniform cylinder. At comparable noise levels, the resolution
achieved with EM and OSEM (0.9-mm to 1.2-mm) is significantly
better than that obtained with FBP or 3DRP (1.5-mm to 2.0-mm.)
Images of a rat skull labeled with 18 F-fluoride suggest that
3D EM and 3D OSEM can improve image quality of a small animal
PET camera
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