Shimadzu LC-MS-IT-TOF High-Speed Liquid Chromatograph Mass Spectrometer

Introduction

In Novermber 2009, Virginia DCLS transfered high resolution LC-MS-IT-TOF to SRIF.

Shimadzu's LCMS-IT-TOF is a novel hybrid mass spectrometer for biomarker discovery, metabolite identification and human health research, and ideal for applications in environmental chemistry, forensics, and drug development. Coupling atmospheric pressure ionization with Ion-Trap (IT) and Time-of-Flight (TOF) technologies, the LCMS-IT-TOF delivers high mass accuracy and high mass resolution (10,000 at 1000 m/z) independent of MS mode.

The LCMS-IT-TOF has been designed to maximize sensitivity and selectivity by optimizing the ion transport to the TOF analyzer and redefining the capability of the quadrupole ion trap. The ion trap is used to focus ions before ejection into the TOF as well as supporting MSn analysis with effective precursor ion selection capabilities (resolution > 1,000 at 1,000 m/z).

Features

The LCMS-IT-TOF allows more qualitative information about a sample to be collected in a single run, enabling researchers and scientists to:

• Elucidate structures of new molecules
• Identify impurities and contaminants
• Analyze metabolites and biomarkers to evaluate biological pathways
• Predict accurate structural details
• Obtain high-sensitivity detection of low concentration samples

Projects

Metabolomics -- Identify unknowns from Caenorhabditis elegans
Gita Sudama and Dr. James Willett, Department of Molecular and Microbiology

Study of Pheo-Melanin in Adipose
Ancha Baranova and Tom Huff Department of Molecular and Microbiology and Share Research Instrumentation Facility

Study of Endocrine disrupting chemicals (EDCs) and Pharmaceutical and Personal Care Products (PPCPs) in river samples
Jeremy Weller and Andrea Lorico, Thomas Jefferson High School for Science and Technology

Location

The Shimadzu's LCMS-IT-TOF is located in SRIF Lab 221 of Discovery Hall, Prince William Campus.

Download

Product Brochure

Advantages of LCMS-IT-TOF Mass Spectrometry in Identifying Polymer Additives

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