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SRIF is designed to accommodate researchers from the various natural-science departments at George Mason University. The facility is housed in Room 221, and several labs on the 3rd floor of Discovery Hall Building on the GMU Prince William campus. SRIF provides a laboratory environment suitable for short-term or continuing analytical investigations. This facility was established by the College of Arts and Sciences to promote interaction among faculty and students from various disciplines.

SRIF is also home to the Center for Biomedical Genomics (CBMG), a multidisciplinary center dedicated to applied genomic research in the biological sciences using new microarray technology.